Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116803 | 0.88 | MAPT (0.38) | MAPTLMNAACACBRAB9AMEN1 | |
| SCHEMBL20676544 | 0.83 | ACACB (0.35) | MAPTLMNAACACBRAB9AMEN1 | |
| SCHEMBL20116686 | 0.81 | MAPT (0.34) | MAPTLMNAACACBRAB9AMEN1 | |
| SCHEMBL20117281 | 0.80 | TBK1 (0.36) | S1PR1S1PR4S1PR5RAB9ANPC1 | |
| SCHEMBL20117208 | 0.78 | MAPT (0.40) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL20117187 | 0.78 | MAPT (0.44) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL20116718 | 0.76 | MAPT (0.40) | MAPTLMNANPC1HTT | |
| SCHEMBL20116656 | 0.76 | S1PR1 (0.36) | MAPTLMNAS1PR1S1PR4S1PR5 | |
| SCHEMBL20116481 | 0.76 | S1PR1 (0.36) | MAPTLMNAS1PR1S1PR4S1PR5 | |
| SCHEMBL20116683 | 0.76 | USP30 (0.40) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |