Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22357745 | 0.83 | CASR (0.34) | — | |
| SCHEMBL20116565 | 0.78 | GRM4 (0.44) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL26373750 | 0.76 | NR1I2 (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL27051630 | 0.76 | RET (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL27051631 | 0.76 | NR1I2 (0.38) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL20117051 | 0.72 | SYK (0.36) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL14817010 | 0.71 | KDM4E (0.42) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL20117058 | 0.70 | HTR2A (0.37) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL20116946 | 0.68 | MPO (0.37) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL20749527 | 0.68 | HTR4 (0.36) | NR1I2EGFRADRA2AADORA3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |