Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10304905 | 0.84 | KMT2A (0.52) | KMT2ALMNAKDM4ESMN1; SMN2P2RX3 | |
| SCHEMBL27035942 | 0.79 | NUDT1 (0.49) | KMT2AP2RX3P2RX2MAPTDHFR | |
| SCHEMBL30729970 | 0.79 | NUDT1 (0.49) | KMT2AP2RX3P2RX2MAPTDHFR | |
| SCHEMBL26997263 | 0.77 | POLB (0.36) | KMT2ALMNAAOC3KDM4EHSD17B10 | |
| SCHEMBL26647089 | 0.74 | LMNA (0.50) | KMT2ALMNAAOC3KDM4EHSD17B10 | |
| SCHEMBL13832839 | 0.74 | AOC3 (0.37) | KMT2ALMNAAOC3KDM4EHSD17B10 | |
| SCHEMBL20116553 | 0.73 | KDM4E (0.51) | LMNAKDM4EHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL907644 | 0.73 | TNFSF11 (0.40) | KMT2AKDM4ESMN1; SMN2POLBHPGD | |
| SCHEMBL9918974 | 0.73 | LMNA (0.38) | KMT2ALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL10216223 | 0.72 | P2RX3 (0.42) | LMNAPOLBP2RX3P2RX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |