Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116816 | 0.86 | TBK1 (0.39) | TBK1KITUSP7SMN1; SMN2SMO | |
| SCHEMBL20676503 | 0.85 | S1PR1 (0.34) | TBK1KIT | |
| SCHEMBL20116814 | 0.85 | USP30 (0.53) | TBK1USP30KITCPT1AHTT | |
| SCHEMBL20116683 | 0.82 | USP30 (0.40) | TBK1USP30KITUSP7SMN1; SMN2 | |
| SCHEMBL20676436 | 0.81 | USP7 (0.41) | USP30KITUSP7SMN1; SMN2SMO | |
| SCHEMBL20116785 | 0.80 | KIT (0.42) | USP30KITUSP7SMN1; SMN2SMO | |
| SCHEMBL20116775 | 0.79 | SMN1; SMN2 (0.41) | TBK1USP30KITUSP7SMN1; SMN2 | |
| SCHEMBL20117281 | 0.78 | TBK1 (0.36) | TBK1USP30KITKDM4ENPC1 | |
| SCHEMBL20117197 | 0.77 | KIT (0.38) | KITSMN1; SMN2SMOLMNA | |
| SCHEMBL20116502 | 0.76 | USP7 (0.39) | TBK1USP30USP7SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |