Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116785 | 0.87 | KIT (0.42) | SMN1; SMN2KITUSP30USP7CPT1A | |
| SCHEMBL20116791 | 0.87 | SMO (0.43) | SMN1; SMN2HSD11B1 | |
| SCHEMBL20676436 | 0.79 | USP7 (0.41) | SMN1; SMN2KITUSP30USP7CPT1A | |
| SCHEMBL20116816 | 0.79 | TBK1 (0.39) | SMN1; SMN2KITTBK1USP7CPT1A | |
| SCHEMBL20117204 | 0.79 | TBK1 (0.38) | SMN1; SMN2KITTBK1USP30USP7 | |
| SCHEMBL20116225 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2HSD11B1KITCNR1USP30 | |
| SCHEMBL20116683 | 0.78 | USP30 (0.40) | SMN1; SMN2HSD11B1KITTBK1USP30 | |
| SCHEMBL20116814 | 0.78 | USP30 (0.53) | KITTBK1USP30CPT1A | |
| SCHEMBL20117293 | 0.76 | HSD11B1 (0.45) | SMN1; SMN2HSD11B1KIT | |
| SCHEMBL20116230 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2HSD11B1KITTBK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |