SCHEMBL20117677

SCHEMBL20117677

Cc1ccc(C#Cc2ccc3c(c2F)-c2c-3cc(C)c(F)c2F)cc1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.33
CA2 P00918 3/20 0.33
CA9 Q16790 3/20 0.33
GRM5 P41594 1/20 0.33
FFAR1 O14842 3/20 0.32
CA1 P00915 2/20 0.32
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20111708 0.81 FFAR1 (0.32) FFAR1KCNH2
SCHEMBL10448697 0.78 GRM5 (0.37) CA12CA2CA9GRM5FFAR1
SCHEMBL20117662 0.78 PTGS2 (0.39)
SCHEMBL12892514 0.77 GRM5 (0.41) CA12CA2CA9GRM5FFAR1
SCHEMBL7857715 0.77 GRM5 (0.41) CA12CA2CA9GRM5FFAR1
SCHEMBL20117904 0.75 PTGS2 (0.37)
SCHEMBL9510036 0.74 GRM5 (0.39) CA12CA2CA9GRM5FFAR1
SCHEMBL4567628 0.74 GRM5 (0.39) CA12CA2CA9GRM5FFAR1
SCHEMBL11891702 0.73 GRM5 (0.44) CA12CA2CA9GRM5FFAR1
SCHEMBL20102616 0.71 TDP2 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3315583-A1 LIQUID CRYSTAL COMPOUND HAVING BIPHENYLENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-05-02 EP disclosed