Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20765259 | 0.81 | ADRB3 (0.40) | ADRB2ADRB1ADRB3ADRA1AADRA1B | |
| SCHEMBL8257719 | 0.81 | MAPT (0.38) | SLC6A3PNMTIDO1KCNH2 | |
| SCHEMBL30781997 | 0.81 | ADRB3 (0.40) | ADRB2ADRB1ADRB3ADRA1AADRA1B | |
| SCHEMBL1155330 | 0.81 | ADRB3 (0.40) | ADRB2ADRB1ADRB3ADRA1AADRA1B | |
| SCHEMBL14878508 | 0.79 | RIPK1 (0.47) | LMNAKDM4EAOC3IDO1 | |
| SCHEMBL1154991 | 0.79 | RIPK1 (0.47) | LMNAKDM4EAOC3IDO1 | |
| SCHEMBL2238829 | 0.78 | MGLL (0.52) | TSHRRAB9A | |
| SCHEMBL4383802 | 0.77 | FAAH (0.36) | TSHRLMNAKCNA5 | |
| SCHEMBL20117521 | 0.77 | ALDH1A1 (0.33) | — | |
| SCHEMBL24933822 | 0.73 | SMN1; SMN2 (0.42) | ADRB1ADRB3TSHRSLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-B1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | PIMCO 2664 LTD (GB) | 2018-05-02 | — | — | EP | disclosed |