Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118288 | 0.78 | RAB9A (0.36) | KMT2AKDM4EALDH1A1HPGDPTPN11 | |
| SCHEMBL24765305 | 0.77 | L3MBTL1 (0.40) | MEN1KMT2ACA2HTTALDH1A1 | |
| SCHEMBL24764311 | 0.72 | MEN1 (0.38) | MEN1KMT2ACTSKCTSSCA2 | |
| SCHEMBL26814991 | 0.69 | CTSS (0.52) | MEN1KMT2ACTSKCTSSCA2 | |
| SCHEMBL20118531 | 0.69 | MEN1 (0.36) | MEN1KMT2AHTTTRPA1PTPRB | |
| SCHEMBL20118820 | 0.68 | F2 (0.34) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL26347288 | 0.67 | MEN1 (0.52) | MEN1KMT2ACTSKCTSSCA2 | |
| SCHEMBL2640762 | 0.67 | CTSS (0.52) | MEN1KMT2ACTSKCTSSCA2 | |
| SCHEMBL25069089 | 0.67 | CTSS (0.52) | MEN1KMT2ACTSKCTSSCA2 | |
| SCHEMBL1752685 | 0.67 | MEN1 (0.52) | MEN1KMT2ACTSKCTSSCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |