Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118347 | 0.78 | MEN1 (0.39) | HPGDALDH1A1KDM4EKMT2APTPN11 | |
| SCHEMBL20118291 | 0.78 | LMNA (0.40) | RAB9ANPC1SMN1; SMN2HDAC8ALDH1A1 | |
| SCHEMBL24765305 | 0.77 | L3MBTL1 (0.40) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL22382076 | 0.71 | ADRB2 (0.39) | RAB9ANPC1ALDH1A1TSHRMAPT | |
| SCHEMBL20118645 | 0.70 | CYP19A1 (0.42) | RAB9ANPC1SMN1; SMN2HPGDTSHR | |
| SCHEMBL20118630 | 0.69 | F2 (0.61) | — | |
| SCHEMBL20118453 | 0.69 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2HPGDCASP1 | |
| SCHEMBL4417206 | 0.66 | PPID (0.47) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKDM4E | |
| SCHEMBL20118820 | 0.66 | F2 (0.34) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL27523391 | 0.64 | PRMT1 (0.45) | NPC1ALDH1A1MAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |