Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118486 | 0.85 | CYP19A1 (0.40) | CYP19A1RAB9AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL24763936 | 0.82 | RAB9A (0.49) | RAB9AMAPTNPSR1SMN1; SMN2GAA | |
| SCHEMBL20118775 | 0.78 | F2 (0.63) | — | |
| SCHEMBL20118453 | 0.77 | RAB9A (0.47) | RAB9AMAPTNPSR1SMN1; SMN2GAA | |
| SCHEMBL20118539 | 0.75 | ADRB2 (0.40) | CYP19A1MAPTSMN1; SMN2HPGDTSHR | |
| SCHEMBL12560520 | 0.74 | SMN1; SMN2 (0.54) | RAB9ASMN1; SMN2NPC1HPGDMEN1 | |
| SCHEMBL20118526 | 0.73 | LMNA (0.57) | RAB9AMAPTNPSR1SMN1; SMN2NPC1 | |
| SCHEMBL10523697 | 0.73 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2NPC1HPGDCRHBP | |
| SCHEMBL10523694 | 0.73 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2NPC1HPGDCRHBP | |
| SCHEMBL9591911 | 0.72 | GAA (0.51) | RAB9AMAPTSMN1; SMN2GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |