Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173766 | 0.82 | ACHE (0.53) | LMNAALDH1A1FAAHBCHEACHE | |
| SCHEMBL20178579 | 0.82 | ACHE (0.44) | MAPK1BCHEACHE | |
| SCHEMBL20118988 | 0.77 | LMNA (0.50) | LMNAALDH1A1MAPK1CYP3A4FAAH | |
| Metolcarb SCHEMBL27347183 | 0.77 | LMNA (0.57) | LMNAALDH1A1MAPK1CYP3A4FAAH | |
| SCHEMBL17171690 | 0.77 | HSD17B1 (0.56) | ALDH1A1MAPK1POLB | |
| Metolcarb SCHEMBL29413999 | 0.76 | LMNA (0.65) | LMNAALDH1A1MAPK1CYP3A4FAAH | |
| Metolcarb SCHEMBL118244 | 0.76 | LMNA (0.65) | LMNAALDH1A1MAPK1CYP3A4FAAH | |
| Metolcarb SCHEMBL27365735 | 0.75 | LMNA (0.54) | LMNAALDH1A1MAPK1CYP3A4FAAH | |
| Metolcarb SCHEMBL11000289 | 0.74 | LMNA (0.62) | LMNAALDH1A1MAPK1CYP3A4FAAH | |
| Metolcarb SCHEMBL11681132 | 0.74 | LMNA (0.62) | LMNAALDH1A1MAPK1CYP3A4FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081285-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |