Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25993393 | 0.78 | IP6K1 (0.43) | MAP4K4MEN1LMNAMAPTKMT2A | |
| SCHEMBL18455367 | 0.78 | NISCH (0.49) | METAP2MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL19403602 | 0.76 | ALDH1A1 (0.42) | METAP2MEN1LMNAMAPTKMT2A | |
| SCHEMBL13978012 | 0.76 | MAP4K4 (0.53) | MAP4K4MAOAAURKAMETAP2ENPP2 | |
| SCHEMBL30500254 | 0.70 | MAOA (0.83) | MAP4K4MAOAMEN1LMNAMAPT | |
| SCHEMBL29403794 | 0.70 | MAOA (0.83) | MAP4K4MAOAMEN1LMNAMAPT | |
| SCHEMBL251095 | 0.70 | MAOA (0.83) | MAP4K4MAOAMEN1LMNAMAPT | |
| SCHEMBL3375366 | 0.68 | MAP4K4 (0.44) | MAP4K4MAOAAURKAMETAP2ENPP2 | |
| Water SCHEMBL2444002 | 0.67 | MAOA (0.79) | MAP4K4MAOAMEN1LMNAMAPT | |
| Methane SCHEMBL21853746 | 0.67 | MAOA (0.79) | MAP4K4MAOAMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081285-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |