Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016548 | 0.86 | MAPK1 (0.50) | — | |
| SCHEMBL6060396 | 0.72 | NPC1 (0.40) | NR4A2 | |
| SCHEMBL28105342 | 0.70 | HCAR2 (0.52) | HCAR2BRS3NR4A2 | |
| SCHEMBL3226195 | 0.69 | NR4A2 (0.54) | HCAR2BRS3NR4A2KDM5AKDM4C | |
| SCHEMBL3121450 | 0.68 | HTR2C (0.42) | SRC | |
| SCHEMBL8882366 | 0.68 | ALDH1A1 (0.48) | NR4A2 | |
| SCHEMBL9938749 | 0.68 | HCAR2 (0.57) | HCAR2BRS3NR4A2KDM5AKDM4C | |
| SCHEMBL29442799 | 0.68 | HCAR2 (0.57) | HCAR2BRS3NR4A2KDM5AKDM4C | |
| SCHEMBL27651389 | 0.68 | LMNA (0.45) | NR4A2 | |
| SCHEMBL902011 | 0.68 | HCAR2 (0.44) | HCAR2NR4A2POLBKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |