Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019963 | 0.75 | NR1D1 (0.32) | — | |
| SCHEMBL20121282 | 0.73 | BACE1 (0.33) | MAPTBACE1HPGD | |
| SCHEMBL21128813 | 0.73 | POLQ (0.30) | — | |
| SCHEMBL5340854 | 0.73 | LMNA (0.45) | MAPTBACE1HPGDGAAMAPK1 | |
| SCHEMBL861090 | 0.73 | L3MBTL1 (0.38) | SMN1; SMN2MAPTBACE1HPGD | |
| SCHEMBL1167434 | 0.72 | CA2 (0.41) | SMN1; SMN2MAPTBACE1HPGDGAA | |
| SCHEMBL25304303 | 0.69 | DAO (0.33) | — | |
| SCHEMBL3125945 | 0.69 | BACE1 (0.30) | BACE1 | |
| SCHEMBL31658767 | 0.69 | MAOB (0.40) | SMN1; SMN2MAPTBACE1HPGDRIPK1 | |
| SCHEMBL21359499 | 0.68 | OGA (0.38) | SMN1; SMN2MAPTBACE1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962386-B2 | Heteroaryl compounds useful as inhibitors of SUMO activating enzyme | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-05-08 | — | — | US | disclosed |