Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | QPCT | Q16769 | 9/20 | 0.41 |
| ▸ | QPCTL | Q9NXS2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19134465 | 0.89 | KDM4E (0.63) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL23639228 | 0.85 | KDM4E (0.48) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL19368366 | 0.81 | KDM4E (0.49) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL19203362 | 0.81 | PRMT3 (0.46) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL19851624 | 0.79 | ADRA2A (0.51) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL18746471 | 0.77 | KDM4E (0.46) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL18610454 | 0.76 | QPCT (0.45) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL18457192 | 0.76 | GRM4 (0.53) | NPC1RAB9APRMT3EHMT2PRMT6 | |
| SCHEMBL25833149 | 0.75 | NPC1 (0.52) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL20625822 | 0.75 | GRM4 (0.44) | KDM4ENPC1ALDH1A1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963447-B2 | Substituted 4-azaindoles and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-08 | — | — | US | disclosed |