Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 11/20 | 0.42 |
| ▸ | QPCTL | Q9NXS2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22871240 | 0.92 | APP (0.38) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL19368366 | 0.92 | KDM4E (0.49) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL20840948 | 0.92 | KDM4E (0.46) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL23136933 | 0.86 | QPCT (0.52) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL21577383 | 0.82 | APP (0.41) | APPERN1CA1CA2CA9 | |
| SCHEMBL20417352 | 0.82 | APP (0.41) | APPBRD4ERN1CA1CA2 | |
| SCHEMBL19134465 | 0.81 | KDM4E (0.63) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL18610454 | 0.80 | QPCT (0.45) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL20121979 | 0.77 | KDM4E (0.52) | KDM4ENPC1ALDH1A1TP53RAB9A | |
| SCHEMBL20341033 | 0.77 | QPCT (0.44) | KDM4ENPC1ALDH1A1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685745-B2 | Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors | DART NEUROSCIENCE, LLC (US) | 2023-06-27 | — | — | US | disclosed |
| US-20220267351-A1 | SUBSTITUTED BENZOXAZOLE AND BENZOFURAN COMPOUNDS AS PDE7 INHIBITORS | DART NEUROSCIENCE, LLC | 2022-08-25 | — | — | US | disclosed |
| US-11091474-B2 | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation | UCB Biopharma SRL (BE) | 2021-08-17 | — | — | US | disclosed |
| US-20200291013-A1 | ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION | UCB BIOPHARMA SPRL (BE) | 2020-09-17 | — | — | US | disclosed |
| US-20180215732-A9 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-08-02 | — | — | US | disclosed |
| US-20180057470-A1 | COMPOUNDS FOR THERAPEUTIC USE | DART NEUROSCIENCE, LLC | 2018-03-01 | — | — | US | disclosed |
| US-20180022733-A1 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-25 | — | — | US | disclosed |
| US-9763949-B2 | EGFR modulators and uses thereof | ACEA BIOSCIENCES INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9623027-B2 | — | — | 2017-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685745-B2 | Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors | PDE7A, PDE7B, PDE8B | KDM4E 2578/4885NPC1 3681/4885ALDH1A1 2216/4885 |
| US-20180022733-A1 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS | P4HA1, PAH, EGLN3 | KDM4E 548/4885NPC1 1042/4885ALDH1A1 46/4885 |
| US-20200291013-A1 | ALKOXY BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION | PARK7, HTT, SNCA | KDM4E 1045/4885NPC1 2684/4885ALDH1A1 4393/4885 |
| US-20180215732-A9 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS | P4HA1, PAH, EGLN3 | KDM4E 548/4885NPC1 1042/4885ALDH1A1 46/4885 |
| US-11091474-B2 | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation | PARK7, HTT, SNCA | KDM4E 1045/4885NPC1 2684/4885ALDH1A1 4393/4885 |
| US-20220267351-A1 | SUBSTITUTED BENZOXAZOLE AND BENZOFURAN COMPOUNDS AS PDE7 INHIBITORS | PDE7A, PDE7B, PDE8B | KDM4E 2578/4885NPC1 3681/4885ALDH1A1 2216/4885 |
| US-20180057470-A1 | COMPOUNDS FOR THERAPEUTIC USE | OPRK1, ACHE, OPRL1 | KDM4E 3883/4885NPC1 341/4885ALDH1A1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.