Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | GOT1 | P17174 | 1/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CTSD | P07339 | 4/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24259971 | 0.83 | RARA (0.36) | LMNARARARARBRARGTDP1 | |
| SCHEMBL8839064 | 0.81 | LMNA (0.51) | LMNARARARARBRARGTDP1 | |
| SCHEMBL20121984 | 0.80 | RARA (0.37) | LMNARARARARBRARGTDP1 | |
| SCHEMBL10171067 | 0.72 | HDAC11 (0.40) | LMNARARARARBRARGTDP1 | |
| SCHEMBL20122013 | 0.71 | HDAC11 (0.61) | LMNARARARARBRARGTDP1 | |
| SCHEMBL19647750 | 0.69 | ALDH1A1 (0.47) | LMNATDP1MEN1PGRKMT2A | |
| SCHEMBL5328881 | 0.68 | KDM4E (0.34) | LMNATDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL8520331 | 0.66 | RARA (0.51) | LMNARARARARBRARGTDP1 | |
| SCHEMBL641031 | 0.65 | RARB (0.67) | LMNARARARARBRARGTDP1 | |
| SCHEMBL10014917 | 0.64 | RARA (0.52) | LMNARARARARBRARGTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963439-B2 | Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-05-08 | — | — | US | disclosed |