Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122454 | 0.88 | MAPT (0.45) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL20122460 | 0.87 | ACE (0.51) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL20122511 | 0.86 | MAPT (0.34) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL20122512 | 0.86 | MAPT (0.34) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL20122510 | 0.84 | HPGD (0.40) | MAPTADAM17KMT2AATMHPGD | |
| SCHEMBL9630054 | 0.83 | MAPT (0.52) | MAPTADAM17KMT2AATMERCC5 | |
| SCHEMBL9630045 | 0.83 | MAPT (0.52) | MAPTADAM17KMT2AATMERCC5 | |
| SCHEMBL11385539 | 0.81 | KMT2A (0.53) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL11385542 | 0.81 | KMT2A (0.53) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL20122403 | 0.80 | CHRM1 (0.32) | MAPTADAM17KMT2AATMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963428-B1 | Bucillamine prodrugs, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2018-05-08 | — | — | US | disclosed |