Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.38 |
| ▸ | FNTB | P49356 | 2/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122473 | 0.88 | MAPT (0.46) | MAPTADAM17KMT2AATMMME | |
| SCHEMBL20122512 | 0.79 | MAPT (0.34) | MAPTADAM17KMT2AATMTSHR | |
| SCHEMBL20122511 | 0.79 | MAPT (0.34) | MAPTADAM17KMT2AATMMME | |
| SCHEMBL20122510 | 0.77 | HPGD (0.40) | MAPTADAM17KMT2AATMNFKB1 | |
| SCHEMBL20122460 | 0.77 | ACE (0.51) | MAPTADAM17KMT2AATMMME | |
| SCHEMBL20122456 | 0.77 | ACE (0.40) | MAPTKMT2AMMEACEACE2 | |
| SCHEMBL11188353 | 0.77 | ELANE (0.55) | MAPTADAM17KMT2AATMMME | |
| SCHEMBL11188356 | 0.77 | ELANE (0.55) | MAPTADAM17KMT2AATMMME | |
| SCHEMBL9705400 | 0.76 | RAB9A (0.54) | KMT2ATSHRKDM4ESMN1; SMN2HPGD | |
| SCHEMBL9705401 | 0.76 | RAB9A (0.54) | KMT2ATSHRKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963428-B1 | Bucillamine prodrugs, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2018-05-08 | — | — | US | disclosed |