Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.46 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29852312 | 0.83 | KDM4E (0.44) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL28194523 | 0.82 | KDM4E (0.46) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL2015751 | 0.81 | LMNA (0.53) | KDM4EKDM5AKDM3AJMJD1CMAPT | |
| SCHEMBL26704130 | 0.81 | KDM4E (0.42) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL31229428 | 0.81 | KDM4E (0.42) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL29795813 | 0.79 | KDM4E (0.44) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL26669209 | 0.79 | KDM4E (0.44) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL9952304 | 0.78 | KDM4E (0.49) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL2032700 | 0.77 | XDH (0.49) | MAPK8KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL9565273 | 0.76 | MAPK8 (0.47) | MAPK8KDM4EMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056449-A1 | COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION (US) | 2022-03-17 | — | — | WO | disclosed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| US-5591853-A | CHEMICAL INTERMEDIATE PRODUCTS FOR PHARMACEUTICALS | LONZA LTD. (CH) | 1997-01-07 | — | — | US | disclosed |
| EP-0552760-A1 | Microbiological process for the preparation of 2-halopyrimidine-4-carboxylic acids | LONZA AG (CH) | 1993-07-28 | — | — | EP | disclosed |