Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | KDM5A | P29375 | 3/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.49 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14495134 | 0.85 | ALDH1A1 (0.42) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL2826624 | 0.83 | ADORA3 (0.37) | KDM4EKDM5AKDM3AJMJD1CTSHR | |
| SCHEMBL18036607 | 0.82 | KDM4E (0.50) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL3281281 | 0.82 | KDM4E (0.51) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL7066012 | 0.81 | ALDH1A1 (0.46) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL25176793 | 0.81 | KDM4E (0.49) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL7368934 | 0.81 | KDM4E (0.49) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL31053756 | 0.81 | KDM4E (0.49) | KDM4EKDM5AKDM3AJMJD1CALOX15 | |
| SCHEMBL16015726 | 0.80 | HCRTR1 (0.50) | KDM4EKDM3AALOX15TSHRALDH1A1 | |
| SCHEMBL20988500 | 0.80 | BRD4 (0.43) | HPGDNPC1RAB9APOLBMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654422-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME | H. Lundbeck A/S (DK) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088365-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2012-06-28 | — | — | WO | disclosed |
| US-20120095001-A1 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | MERCK SHARP & DOHME CORP. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095001-A1 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | HIF1AN, HIF1A, EGLN2 | KDM4E 100/4885KDM5A 127/4885KDM3A 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.