Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423443 | 0.80 | ACHE (0.47) | PAOXKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL20123338 | 0.79 | — | — | |
| SCHEMBL20123404 | 0.77 | ACHE (0.44) | KDM4ETSHRACHEALDH1A1L3MBTL1 | |
| SCHEMBL3911056 | 0.77 | ACHE (0.59) | PAOXKDM4EMAPK1HIF1AACHE | |
| SCHEMBL21359262 | 0.77 | ACHE (0.70) | ACHE | |
| SCHEMBL20123390 | 0.77 | PAOX (0.45) | PAOXKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL5463166 | 0.77 | KDM4E (0.52) | PAOXKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL8107 | 0.75 | KDM4E (0.71) | PAOXKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL16658578 | 0.75 | SMN1; SMN2 (0.49) | KDM4EMAPK1HIF1ATSHRACHE | |
| SCHEMBL20123376 | 0.75 | DNM1 (0.41) | ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |