Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18926549 | 0.91 | LTA4H (0.59) | KDM4ELTA4HSIGMAR1HRH3ALDH1A1 | |
| SCHEMBL19043759 | 0.89 | LTA4H (0.51) | L3MBTL1KDM4EMEN1KMT2ALTA4H | |
| SCHEMBL7983264 | 0.82 | CYP2D6 (0.57) | KMT2ALTA4HSIGMAR1HRH3ALDH1A1 | |
| SCHEMBL2088826 | 0.81 | SIGMAR1 (0.45) | L3MBTL1KDM4EMEN1KMT2ASIGMAR1 | |
| SCHEMBL11248323 | 0.81 | L3MBTL1 (0.74) | L3MBTL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL791288 | 0.81 | CYP2D6 (0.55) | LTA4HSIGMAR1HRH3ALDH1A1DRD2 | |
| SCHEMBL19043541 | 0.79 | HRH3 (0.80) | KDM4ELTA4HSIGMAR1HRH3SLC6A3 | |
| SCHEMBL23644081 | 0.78 | SIGMAR1 (0.45) | L3MBTL1KDM4EMEN1KMT2ALTA4H | |
| SCHEMBL7923985 | 0.78 | HRH3 (0.82) | MEN1KMT2ASIGMAR1HRH3ALDH1A1 | |
| SCHEMBL18934284 | 0.78 | SIGMAR1 (0.51) | L3MBTL1SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318277-A1 | INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE FOR THE TREATMENT OF MOTOR NEURON DISEASES | Institut du Cerveau et de la Moelle Epiniere-ICM (FR) | 2018-05-09 | — | — | EP | disclosed |