Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | NPM1 | P06748 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GLP1R | P43220 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31550542 | 0.83 | SIK1 (0.40) | NPM1ALKMEN1KMT2ANPC1 | |
| SCHEMBL20698048 | 0.79 | PARP1 (0.34) | LMNAHPGDMAPK1HTTALDH1A1 | |
| SCHEMBL2144640 | 0.78 | DYRK1A (0.51) | FABP4NPM1ALKMEN1KMT2A | |
| SCHEMBL3489965 | 0.73 | NPC1 (0.51) | FABP4NPM1ALKMEN1KMT2A | |
| SCHEMBL1940039 | 0.73 | NPC1 (0.52) | FABP4MEN1KMT2ANPC1LMNA | |
| SCHEMBL23877945 | 0.73 | CYP11B1 (0.45) | HCAR1HTTBACE1 | |
| SCHEMBL18009808 | 0.73 | GLP1R (0.47) | FABP4NPM1ALKMEN1KMT2A | |
| SCHEMBL15272387 | 0.72 | LMNA (0.60) | MEN1KMT2ANPC1LMNAMAPT | |
| SCHEMBL10986832 | 0.72 | HTT (0.62) | HPGDMAPK1HTTALDH1A1 | |
| SCHEMBL12502297 | 0.72 | FABP4 (0.40) | FABP4NPM1ALKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127388-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127388-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | FABP4 3301/4885NPM1 3462/4885ALK 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.