Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129160 | 0.96 | FAAH (0.37) | SGMS2PIK3CDFAAHBTKGPR119 | |
| SCHEMBL27098038 | 0.94 | SGMS2 (0.34) | SGMS2PIK3CDFAAHBTKGPR119 | |
| SCHEMBL20129278 | 0.92 | GPR119 (0.40) | SGMS2PIK3CDBTKGPR119TBK1 | |
| SCHEMBL29547814 | 0.92 | SGMS2 (0.37) | SGMS2PIK3CDFAAHBTKGPR119 | |
| SCHEMBL27097899 | 0.92 | SGMS2 (0.37) | SGMS2PIK3CDFAAHBTKGPR119 | |
| SCHEMBL27152337 | 0.92 | SGMS2 (0.37) | SGMS2PIK3CDFAAHBTKGPR119 | |
| SCHEMBL27097880 | 0.92 | TBK1 (0.39) | SGMS2PIK3CDGPR119PIK3CATBK1 | |
| SCHEMBL20129176 | 0.92 | SGMS2 (0.34) | SGMS2PIK3CDFAAHBTKGPR119 | |
| SCHEMBL20233826 | 0.90 | GPR119 (0.39) | SGMS2PIK3CDBTKGPR119PIK3CA | |
| SCHEMBL20129147 | 0.90 | FAAH (0.41) | SGMS2PIK3CDFAAHBTKGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2018102067-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | SGMS2 4756/4885PIK3CD 2235/4885FAAH 4345/4885 |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | SGMS2 4762/4885PIK3CD 2652/4885FAAH 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.