SCHEMBL2012945

SCHEMBL2012945

Cc1c[c]ccc1-c1cccc(F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.39
PDE3B Q13370 1/20 0.39
PDE3A Q14432 1/20 0.39
TAAR1 Q96RJ0 2/20 0.38
ESR2 Q92731 1/20 0.38
TNKS2 Q9H2K2 1/20 0.38
MGAM O43451 1/20 0.38
GAA P10253 1/20 0.38
SI P14410 1/20 0.38
MGAM2 Q2M2H8 1/20 0.38
RAPGEF4 Q8WZA2 1/20 0.37
NPSR1 Q6W5P4 2/20 0.36
PGR P06401 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HPGD P15428 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
NISCH Q9Y2I1 1/20 0.36
CDC7 O00311 1/20 0.35
ROCK2 O75116 1/20 0.35
MAP4K4 O95819 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2012935 0.84 RAPGEF4 (0.32) RAPGEF4PGR
SCHEMBL4209132 0.82 TAAR1 (0.40) PDE3BPDE3ATAAR1ESR2NPSR1
SCHEMBL5634702 0.82 ACHE (0.39) ACHEHPGDNISCHMAP4K4PIM1
SCHEMBL7873514 0.79 ESR2 (0.45) TAAR1ESR2MGAMGAASI
SCHEMBL2013350 0.79 TAAR1 (0.38) TAAR1ESR2NPSR1KDM4EHPGD
SCHEMBL16720132 0.79 ESR2 (0.46) TAAR1ESR2NPSR1KDM4EHPGD
SCHEMBL16720001 0.79 PDGFRB (0.43) KDM4EHPGDRELA
SCHEMBL695042 0.79 RAPGEF4 (0.41) RAPGEF4KDM4EHPGDSMN1; SMN2
SCHEMBL27707563 0.79 TAAR1 (0.40) PDE3BPDE3ATAAR1ESR2NPSR1
SCHEMBL2011911 0.78 ACHE (0.36) ACHEPDE3BPDE3ATNKS2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed