SCHEMBL2013154

SCHEMBL2013154

Cc1[c]ccc(-c2cc(F)cc(F)c2)c1

nearest known ligand 0.37

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PGR P06401 3/20 0.36
MAP4K4 O95819 1/20 0.32
NOTUM Q6P988 1/20 0.31
GRM5 P41594 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28667348 0.87 PGR (0.41) PGRMAP4K4
SCHEMBL1939273 0.84 ALDH1A1 (0.31)
SCHEMBL2012498 0.84 TAAR1 (0.46) PGRNOTUM
SCHEMBL2014607 0.83 TNKS2 (0.39) PGRMAP4K4
SCHEMBL2432908 0.78 CYP17A1 (0.37) PGRNOTUM
SCHEMBL2011823 0.75 PGR (0.33) PGRMAP4K4NOTUM
SCHEMBL161280 0.75
SCHEMBL6191317 0.75 ABCB1 (0.35) PGR
SCHEMBL2154634 0.74 MCL1 (0.41)
SCHEMBL694507 0.74 ALDH1A1 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed