Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 4/20 | 0.31 |
| ▸ | CTSD | P07339 | 3/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013154 | 0.87 | PGR (0.36) | PGRMAP4K4 | |
| SCHEMBL694738 | 0.77 | PTGS2 (0.40) | PGRRAPGEF4 | |
| SCHEMBL1939273 | 0.77 | ALDH1A1 (0.31) | — | |
| SCHEMBL2012498 | 0.77 | TAAR1 (0.46) | PGR | |
| SCHEMBL2014607 | 0.76 | TNKS2 (0.39) | PGRMAP4K4 | |
| SCHEMBL512419 | 0.76 | ALOX5 (0.42) | PGRBACE1 | |
| SCHEMBL534111 | 0.76 | MAP4K4 (0.41) | PGRMAP4K4RAPGEF4BRD4 | |
| SCHEMBL2432908 | 0.74 | CYP17A1 (0.37) | PGRRAPGEF4 | |
| SCHEMBL12999492 | 0.72 | PGR (0.46) | PGRMAP4K4RAPGEF4 | |
| SCHEMBL2011823 | 0.72 | PGR (0.33) | PGRMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113874350-A | tetrahydro-1H-cyclopenta [ CD ] indene derivatives as hypoxia inducible factor-2 (alpha) inhibitors | 尼坎治疗公司 | 2021-12-31 | — | — | CN | claimed |