Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 8/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012926 | 0.94 | SMO (0.48) | L3MBTL1CNR2SMONPC1RAB9A | |
| SCHEMBL2017715 | 0.91 | MTNR1A (0.41) | L3MBTL1CNR2NPC1RAB9AALOX12 | |
| SCHEMBL2013778 | 0.91 | NPC1 (0.44) | L3MBTL1SMONPC1RAB9AALOX12 | |
| SCHEMBL2017849 | 0.85 | NPC1 (0.48) | L3MBTL1CNR2SMONPC1RAB9A | |
| SCHEMBL2017854 | 0.85 | NPC1 (0.48) | L3MBTL1CNR2SMONPC1RAB9A | |
| SCHEMBL2016578 | 0.84 | CNR2 (0.38) | L3MBTL1CNR2SMONPC1RAB9A | |
| SCHEMBL2011479 | 0.83 | METAP2 (0.43) | L3MBTL1CNR2NPC1RAB9AALOX12 | |
| SCHEMBL2011476 | 0.83 | METAP2 (0.43) | L3MBTL1CNR2NPC1RAB9AALOX12 | |
| SCHEMBL2013325 | 0.83 | NPC1 (0.50) | L3MBTL1CNR2SMONPC1RAB9A | |
| SCHEMBL2015791 | 0.82 | METAP2 (0.42) | L3MBTL1NPC1RAB9AALOX12METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |