Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 7/20 | 0.46 |
| ▸ | NOS3 | P29474 | 4/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8283148 | 1.00 | TSHR (0.48) | TSHRCA12CA7CA9CA14 | |
| SCHEMBL15865986 | 0.87 | ESR1 (0.41) | MEN1KMT2AESR1ESR2 | |
| SCHEMBL8283121 | 0.87 | L3MBTL1 (0.44) | MEN1KMT2AHPGDESR1ESR2 | |
| SCHEMBL15159050 | 0.87 | L3MBTL1 (0.44) | MEN1KMT2AHPGDESR1ESR2 | |
| SCHEMBL8532710 | 0.85 | SLC6A4 (0.54) | HTT | |
| SCHEMBL23551731 | 0.85 | TSHR (0.50) | TSHRCA12CA7CA9CA14 | |
| SCHEMBL1531741 | 0.85 | ALDH1A1 (0.52) | CA12CA7CA9CA14MEN1 | |
| SCHEMBL13386099 | 0.85 | ALDH1A1 (0.52) | CA12CA7CA9CA14MEN1 | |
| SCHEMBL29077049 | 0.85 | ALDH1A1 (0.52) | CA12CA7CA9CA14MEN1 | |
| SCHEMBL1531738 | 0.85 | ALDH1A1 (0.52) | CA12CA7CA9CA14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | REN, MAN2B2, UTS2R | TSHR 2870/4885CA12 4430/4885CA7 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.