SCHEMBL20134754

SCHEMBL20134754

Cc1cc(C)c2c(C3CCN(C(=O)c4ccc(C5(C)NC(=O)NC5=O)cc4)CC3)n[nH]c2c1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
MAPK7 Q13164 7/20 0.38
ALDH1A1 P00352 1/20 0.36
ABL1 P00519 3/20 0.36
BCR P11274 3/20 0.36
ADAM17 P78536 3/20 0.35
ADAMTS5 Q9UNA0 1/20 0.35
POLB P06746 1/20 0.35
FASN P49327 1/20 0.34
CRBN Q96SW2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20134753 1.00 KMT2A (0.39) KMT2AMEN1MAPK7ALDH1A1ABL1
SCHEMBL29688681 1.00 KMT2A (0.39) KMT2AMEN1MAPK7ALDH1A1ABL1
SCHEMBL20134865 0.91 MAPK7 (0.38) KMT2AMEN1MAPK7ABL1BCR
SCHEMBL20134862 0.91 MAPK7 (0.38) KMT2AMEN1MAPK7ABL1BCR
SCHEMBL29688407 0.91 MAPK7 (0.38) KMT2AMEN1MAPK7ABL1BCR
SCHEMBL20135383 0.88 KMT2A (0.37) KMT2AMEN1MAPK7ALDH1A1ABL1
SCHEMBL29689349 0.88 KMT2A (0.37) KMT2AMEN1MAPK7ALDH1A1ABL1
SCHEMBL20135382 0.88 KMT2A (0.37) KMT2AMEN1MAPK7ALDH1A1ABL1
SCHEMBL20134810 0.83 KMT2A (0.38) KMT2AMEN1MAPK7ALDH1A1ADAM17
SCHEMBL20134807 0.83 KMT2A (0.38) KMT2AMEN1MAPK7ALDH1A1ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 US claimed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 US claimed
EP-3321256-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2018-05-16 EP claimed
US-10407408-B2 Imide derivatives and use thereof as medicine MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-09-10 US disclosed
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-03-14 US disclosed
EP-3321256-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2018-05-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190077787-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP1 KMT2A 2568/4885MEN1 3735/4885MAPK7 390/4885
US-10407408-B2 Imide derivatives and use thereof as medicine MMP9, MMP2, MMP1 KMT2A 2539/4885MEN1 2913/4885MAPK7 302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.