SCHEMBL20134833

SCHEMBL20134833

CC(C)[C@]1(c2ccc([C]=O)cc2)NC(=O)NC1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.41
CACNA1F O60840 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
HTR2A P28223 1/20 0.36
HRH1 P35367 1/20 0.36
SCN1A P35498 1/20 0.36
SCN4A P35499 1/20 0.36
BLM P54132 1/20 0.36
PMP22 Q01453 1/20 0.36
CACNA1D Q01668 1/20 0.36
KCNH2 Q12809 1/20 0.36
CACNA1S Q13698 1/20 0.36
CACNA1C Q13936 1/20 0.36
SCN5A Q14524 1/20 0.36
SCN2A Q99250 1/20 0.36
SCN3A Q9NY46 1/20 0.36
AKR1B1 P15121 1/20 0.34
GAA P10253 1/20 0.34
MMP2 P08253 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20134752 0.81 ADAM17 (0.45) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL4232196 0.81 CYP2C9 (0.55) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL20134939 0.76 AKR1B1 (0.40) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL20134941 0.76 AKR1B1 (0.40) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL20135355 0.75 AKR1B1 (0.36) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL20135356 0.75 AKR1B1 (0.36) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL20134891 0.71 MMP14 (0.40) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL542293 0.69 AKR1B10 (0.39) MAPTAKR1B1GAALMNA
SCHEMBL11010656 0.68 CYP2C9 (0.47) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL20135629 0.67 AKR1B1 (0.35) CYP2C9CACNA1FALDH1A1MAPTHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3321256-A1 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2018-05-16 EP disclosed