Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | TAF1 | P21675 | 2/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20135063 | 1.00 | CHEK1 (0.33) | CHEK1KCNH2NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL29688904 | 0.99 | CHEK1 (0.32) | CHEK1KCNH2NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL29688682 | 0.99 | CHEK1 (0.32) | CHEK1KCNH2NOS3NOS1NOS2 | |
| SCHEMBL20135148 | 0.82 | CHEK1 (0.41) | CHEK1NOS3NOS1NOS2PAK1 | |
| SCHEMBL20134866 | 0.80 | CHEK1 (0.42) | CHEK1PAK1CHEK2 | |
| SCHEMBL20135318 | 0.79 | CHEK2 (0.31) | CHEK1NOS3NOS1NOS2CHEK2 | |
| SCHEMBL20134820 | 0.79 | CHEK2 (0.38) | CHEK1KCNH2PAK1JAK3BRD4 | |
| Hydrochloric Acid SCHEMBL29688666 | 0.79 | CHEK1 (0.42) | CHEK1PAK1CHEK2 | |
| SCHEMBL20135028 | 0.78 | CHEK2 (0.51) | CHEK1PAK1CHEK2 | |
| Hydrochloric Acid SCHEMBL29688683 | 0.78 | CHEK2 (0.37) | CHEK1KCNH2PAK1JAK3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407408-B2 | Imide derivatives and use thereof as medicine | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20190077787-A1 | NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-03-14 | — | — | US | disclosed |
| EP-3321256-A1 | NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE | Mitsubishi Tanabe Pharma Corporation (JP) | 2018-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077787-A1 | NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE | MMP9, MMP10, MMP1 | CHEK1 4792/4885KCNH2 4628/4885NOS3 94/4885 |
| US-10407408-B2 | Imide derivatives and use thereof as medicine | MMP9, MMP2, MMP1 | CHEK1 4797/4885KCNH2 4559/4885NOS3 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.