Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20135224 | 1.00 | ADAMTS5 (0.38) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20135363 | 0.88 | UBE2M (0.39) | MMP2UBE2MDCUN1D1HPGDALDH1A1 | |
| SCHEMBL20135362 | 0.88 | UBE2M (0.39) | MMP2UBE2MDCUN1D1HPGDALDH1A1 | |
| SCHEMBL29688486 | 0.87 | HSD11B1 (0.35) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20135001 | 0.87 | HSD11B1 (0.35) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20134839 | 0.85 | ADAMTS5 (0.42) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20135476 | 0.85 | ADAM17 (0.39) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20135479 | 0.85 | ADAM17 (0.39) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20134838 | 0.85 | ADAMTS5 (0.42) | ADAMTS5ADAM17MMP2MMP13UBE2M | |
| SCHEMBL20135570 | 0.83 | ADAMTS5 (0.38) | ADAMTS5ADAM17MMP2MMP13UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321256-A1 | NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE | Mitsubishi Tanabe Pharma Corporation (JP) | 2018-05-16 | — | — | EP | disclosed |