Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20578701 | 0.82 | TSHR (0.52) | ALDH1A1TSHRTRIM24TRIM33KMT2A | |
| SCHEMBL14876792 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TSHRTRIM24TRIM33KMT2A | |
| SCHEMBL12578985 | 0.80 | NOS3 (0.52) | ALDH1A1TSHRNOS3NOS1NOS2 | |
| SCHEMBL28653899 | 0.79 | TRIM24 (0.46) | ALDH1A1TSHRTRIM24TRIM33KMT2A | |
| SCHEMBL14840458 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TSHRTRIM24TRIM33KMT2A | |
| SCHEMBL16030976 | 0.78 | ERN1 (0.48) | TRIM24TRIM33KMT2AMEN1LMNA | |
| SCHEMBL14582402 | 0.77 | ALDH1A1 (0.42) | ALDH1A1TSHRTRIM24TRIM33NOS3 | |
| SCHEMBL20578707 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TSHRTRIM24TRIM33CCR1 | |
| SCHEMBL14582403 | 0.75 | ALDH1A1 (0.61) | ALDH1A1TSHRTRIM24TRIM33KMT2A | |
| SCHEMBL20135919 | 0.74 | NOS2 (0.35) | ALDH1A1TSHRTRIM24TRIM33NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | claimed |