Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549325 | 0.84 | KDM1A (0.50) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL5547560 | 0.84 | KDM1A (0.53) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| Hydrochloric Acid SCHEMBL15824893 | 0.81 | KDM1A (0.54) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL809019 | 0.80 | KDM5A (0.52) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL18898122 | 0.80 | KDM1A (0.50) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL29417922 | 0.79 | SIGMAR1 (0.49) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL29417920 | 0.79 | SIGMAR1 (0.49) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL9665166 | 0.79 | KDM5A (0.51) | KDM1AMEN1KMT2AKDM5AKDM4C | |
| Ethylene Glycol SCHEMBL870255 | 0.79 | KDM1A (0.51) | KDM1AMEN1KMT2ASIGMAR1EBP | |
| SCHEMBL27525590 | 0.78 | SIGMAR1 (0.49) | KDM1AMEN1KMT2AKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233146-B2 | Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180134654-A1 | ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134654-A1 | ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS | ACOX3, ACOT7, ACOX1 | KDM1A 2909/4885MEN1 3215/4885KMT2A 2593/4885 |
| US-10233146-B2 | Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis | ACOX3, ACOT7, ACOX1 | KDM1A 2917/4885MEN1 3187/4885KMT2A 2612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.