Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL809019 | 0.86 | KDM5A (0.52) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL9663754 | 0.82 | NOTUM (0.47) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL5549325 | 0.81 | KDM1A (0.50) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL6683861 | 0.81 | KDM5A (0.50) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL20136561 | 0.79 | KDM1A (0.51) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL5547560 | 0.77 | KDM1A (0.53) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL18898122 | 0.77 | KDM1A (0.50) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL29417920 | 0.76 | SIGMAR1 (0.49) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL3706515 | 0.76 | DGAT1 (0.45) | KDM5AKDM4CKDM5BHDAC9ALDH1A1 | |
| SCHEMBL29417922 | 0.76 | SIGMAR1 (0.49) | KDM5AKDM4CKDM5BKDM1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360324-B1 | TRICYCLIC AROMATASE INHIBITORS | AKZO N.V. (NL) | 1992-11-11 | — | — | EP | disclosed |
| US-5019585-A | Tricyclic aromatase inhibitors | AKZO N.V. (NL) | 1991-05-28 | — | — | US | disclosed |
| EP-0360324-A1 | Tricyclic aromatase inhibitors | AKZO N.V. (NL) | 1990-03-28 | — | — | EP | disclosed |