Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706515 | 0.90 | DGAT1 (0.45) | KDM5AKDM4CKDM5BHDAC9TP53 | |
| SCHEMBL6683861 | 0.88 | KDM5A (0.50) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL9665166 | 0.86 | KDM5A (0.51) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL3427486 | 0.82 | ALDH1A1 (0.45) | CYP3A4SIGMAR1 | |
| SCHEMBL12809127 | 0.81 | KDM5A (0.45) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL6684521 | 0.81 | KDM5A (0.47) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL20136561 | 0.80 | KDM1A (0.51) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL15673547 | 0.79 | NR3C1 (0.44) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL5549325 | 0.79 | KDM1A (0.50) | KDM5AKDM4CKDM5BKDM1AMEN1 | |
| SCHEMBL3431949 | 0.79 | POLA1 (0.49) | KDM1ACYP3A4TSHRCYP2C19SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794563-B1 | HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-9255090-B2 | Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-02-09 | — | — | US | disclosed |
| US-20150252036-A1 | Heterocyclyl Derivatives and their use as Prostaglandin D2 Receptor Modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2015-09-10 | — | — | US | disclosed |
| US-8962526-B2 | Herbicidal composition and method of use thereof | SYNGENTA PARTICIPATIONS AG (CH) | 2015-02-24 | — | — | US | disclosed |
| EP-2794563-A1 | HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093842-A1 | HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-06-27 | — | — | WO | disclosed |
| EP-1776119-B9 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | disclosed |
| US-20120088669-A1 | HERBICIDAL COMPOSITION AND METHOD OF USE THEREOF | SYNGENTA LIMITED (GB) | 2012-04-12 | — | — | US | disclosed |
| EP-1776119-B1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-01-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252036-A1 | Heterocyclyl Derivatives and their use as Prostaglandin D2 Receptor Modulators | PTGDR, PTGER1, PTGDR2 | KDM5A 4053/4885KDM4C 4444/4885KDM5B 4112/4885 |
| US-20120088669-A1 | HERBICIDAL COMPOSITION AND METHOD OF USE THEREOF | HPD, TRHDE, DDT | KDM5A 1020/4885KDM4C 282/4885KDM5B 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.