Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952973 | 0.87 | GRIN2D (0.31) | — | |
| SCHEMBL9952150 | 0.85 | AR (0.36) | ARTAAR1PTPN11P2RX7PTGS2 | |
| SCHEMBL2017946 | 0.81 | LMNA (0.37) | ARMEN1MAPTKMT2APTGS2 | |
| SCHEMBL2015782 | 0.78 | NT5E (0.36) | TAAR1ADORA2AKDM4EMEN1MAPT | |
| SCHEMBL3907818 | 0.77 | AR (0.41) | ARTAAR1PTGS2 | |
| SCHEMBL2013729 | 0.74 | TRPM8 (0.38) | TAAR1ADORA1ADORA2APTPN11KDM4E | |
| SCHEMBL10279064 | 0.73 | PIK3CD (0.41) | TAAR1ADORA1ADORA2AKDM4EMEN1 | |
| SCHEMBL2015005 | 0.72 | PIK3CD (0.44) | KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2015518 | 0.72 | ADORA1 (0.32) | TAAR1ADORA1ADORA2APTPN11 | |
| SCHEMBL2017111 | 0.71 | NLRP3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |