Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013163 | 0.83 | FBP1 (0.31) | — | |
| SCHEMBL2015516 | 0.78 | TRPM8 (0.36) | ADORA1ADORA2AADORA2BTAAR1PTPN11 | |
| SCHEMBL2013731 | 0.72 | AR (0.36) | ADORA1ADORA2ATAAR1PTPN11 | |
| SCHEMBL3907818 | 0.69 | AR (0.41) | TAAR1 | |
| SCHEMBL2015127 | 0.67 | CSNK1D (0.35) | ADORA1 | |
| SCHEMBL2015218 | 0.67 | CDC7 (0.40) | — | |
| SCHEMBL7493782 | 0.65 | TAAR1 (0.50) | TAAR1 | |
| SCHEMBL14783969 | 0.65 | DCLRE1B (0.47) | TAAR1 | |
| SCHEMBL18097560 | 0.64 | FFAR1 (0.34) | — | |
| SCHEMBL2013162 | 0.64 | FBP1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |