Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.37 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124023 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2LMNACLK4 | |
| SCHEMBL6869992 | 0.74 | ALDH1A1 (0.47) | ALDH1A1ALDH1A3ALDH3A1KDM4ESMN1; SMN2 | |
| Benzaldehyde SCHEMBL28231985 | 0.73 | ALDH1A1 (0.67) | ALDH1A1ALDH1A3ALDH3A1KDM4ELMNA | |
| SCHEMBL61036 | 0.71 | CLK4 (0.47) | ALDH1A1ALDH1A3ALDH3A1KDM4ESMN1; SMN2 | |
| SCHEMBL6847816 | 0.70 | CYP2A6 (0.42) | ALDH1A1KDM4ESMN1; SMN2LMNACYP2A6 | |
| SCHEMBL11823541 | 0.70 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2LMNADRD2 | |
| 4-Hydroxybenzaldehyde SCHEMBL9594896 | 0.70 | ALDH5A1 (0.70) | ALDH1A1ALDH1A3ALDH3A1KDM4ECYP2A6 | |
| SCHEMBL6685962 | 0.69 | CLK4 (0.64) | ALDH1A1KDM4ESMN1; SMN2LMNACLK4 | |
| SCHEMBL5799195 | 0.69 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2LMNACLK4 | |
| SCHEMBL5799192 | 0.69 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2LMNACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10487076-B2 | Compositions and methods for treating diseases and conditions | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-11-26 | — | — | US | disclosed |
| US-20180134693-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10487076-B2 | Compositions and methods for treating diseases and conditions | C1S, SLC10A1, C1R | ALDH1A1 1801/4885ALDH1A3 2698/4885ALDH3A1 867/4885 |
| US-20180134693-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | C1S, SLC10A1, C1R | ALDH1A1 1801/4885ALDH1A3 2698/4885ALDH3A1 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.