SCHEMBL20138460

SCHEMBL20138460

O=C(c1ccccc1)c1ccc(C#CCBr)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
SRD5A2 P31213 1/20 0.48
GAA P10253 1/20 0.45
ATM Q13315 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
RAB9A P51151 4/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
MAPK13 O15264 1/20 0.43
MAPK12 P53778 1/20 0.43
MAPK11 Q15759 1/20 0.43
MAPK14 Q16539 1/20 0.43
MMP2 P08253 3/20 0.42
MMP12 P39900 3/20 0.42
PTPN1 P18031 1/20 0.42
GSK3B P49841 1/20 0.42
HPGD P15428 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16582658 0.81 CES2 (0.62) ALDH1A1SRD5A2GAAATMTDP1
SCHEMBL1744898 0.81 ALDH1A1 (0.64) ALDH1A1SRD5A2GAAATMTDP1
SCHEMBL26668399 0.79 MMP2 (0.55) ALDH1A1SRD5A2GAAATMTDP1
SCHEMBL10411918 0.79 ALDH1A1 (0.61) ALDH1A1SRD5A2GAAATMTDP1
SCHEMBL1151193 0.78 CYP1A2 (0.58) ALDH1A1MEN1KMT2ALMNAMAPT
SCHEMBL28847017 0.78 ACACB (0.46) ALDH1A1GAAL3MBTL1RAB9AKMT2A
SCHEMBL20208922 0.75 CYP1A2 (0.54) ALDH1A1MEN1KMT2AMAPTMMP2
SCHEMBL29643334 0.75 ALDH1A1 (0.46) ALDH1A1SRD5A2GAAATMTDP1
SCHEMBL16582661 0.74 ALDH1A1 (0.61) ALDH1A1SRD5A2ATMTDP1L3MBTL1
Benzophenone SCHEMBL28027212 0.73 ALDH1A1 (0.82) ALDH1A1SRD5A2ATMTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11065187-B2 Particle bound photosensitizer molecule with reduced toxicity INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2021-07-20 US disclosed
US-20190336425-A1 PARTICLE BOUND PHOTOSENSITIZER MOLECULE WITH REDUCED TOXICITY INTERNATIONAL BUSINESS MACHINES CORPORATION 2019-11-07 US disclosed
US-10413495-B2 Particle bound photosensitizer molecule with reduced toxicity INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-09-17 US disclosed
US-20180133134-A1 PARTICLE BOUND PHOTOSENSITIZER MOLECULE WITH REDUCED TOXICITY INTERNATIONAL BUSINESS MACHINES CORPORATION 2018-05-17 US disclosed