SCHEMBL1744898

SCHEMBL1744898

O=C(c1ccccc1)c1ccc(C#Cc2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.64
SRD5A2 P31213 1/20 0.60
APP P05067 1/20 0.55
ATM Q13315 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
FFAR1 O14842 4/20 0.53
MEN1 O00255 2/20 0.52
RAB9A P51151 2/20 0.52
KMT2A Q03164 2/20 0.52
LMNA P02545 1/20 0.52
MAPT P10636 1/20 0.52
MAPK13 O15264 1/20 0.52
MAPK12 P53778 1/20 0.52
MAPK11 Q15759 1/20 0.52
MAPK14 Q16539 1/20 0.52
GRM5 P41594 2/20 0.50
NPC1 O15118 1/20 0.50
HPGD P15428 1/20 0.50
FFAR4 Q5NUL3 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5072017 0.90 LMNA (0.62) ALDH1A1SRD5A2APPTDP1L3MBTL1
SCHEMBL10411918 0.89 ALDH1A1 (0.61) ALDH1A1SRD5A2ATMTDP1L3MBTL1
SCHEMBL5744049 0.88 MAPT (0.69) ALDH1A1SRD5A2APPFFAR1MEN1
SCHEMBL16582661 0.88 ALDH1A1 (0.61) ALDH1A1SRD5A2ATMTDP1L3MBTL1
SCHEMBL1746493 0.88 MMP2 (0.55) ALDH1A1SRD5A2APPFFAR1LMNA
SCHEMBL6368721 0.88 VCP (0.66) ALDH1A1SRD5A2FFAR1MEN1RAB9A
SCHEMBL4358220 0.88 SRD5A2 (0.59) ALDH1A1SRD5A2APPL3MBTL1FFAR1
SCHEMBL12445832 0.87 MAPT (0.59) ALDH1A1SRD5A2ATML3MBTL1FFAR1
SCHEMBL6675223 0.86 CES2 (0.68) APPFFAR1RAB9AGRM5FFAR4
SCHEMBL18159036 0.86 SRD5A2 (0.65) ALDH1A1SRD5A2FFAR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582722-B1 Phenylethynylbenzophenone-endcapped hyperbranched poly(arylene-ether-ketone-imides) THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 2009-09-01 US claimed
US-12215195-B1 Cross-linkable thermoplastics, and processes of making and using same UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 2025-02-04 US disclosed
US-11840607-B1 Cross-linkable thermoplastics, and processes of making and using same UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 2023-12-12 US disclosed
US-20210188758-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS VTVX HOLDINGS II LLC 2021-06-24 US disclosed
US-10947180-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists VTV THERAPEUTICS LLC (US) 2021-03-16 US disclosed
US-20200215073-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS HIGH POINT PHARMACEUTICALS, LLC 2020-07-09 US disclosed
EP-3080189-B1 POLYMERIC MATERIALS VICTREX MFG LTD (GB) 2020-02-12 EP disclosed
US-10471066-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists VTV THERAPEUTICS LLC (US) 2019-11-12 US disclosed
US-20180071304-A1 Phenoxy Acetic Acids and Phenyl Propionic Acids as PPAR Delta Agonists HIGH POINT PHARMACEUTICALS, LLC 2018-03-15 US disclosed
US-9855274-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists VTV THERAPEUTICS LLC (US) 2018-01-02 US disclosed
US-7582722-B1 Phenylethynylbenzophenone-endcapped hyperbranched poly(arylene-ether-ketone-imides) THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 2009-09-01 US disclosed
US-20090093484-A1 NOVEL COMPOUNDS, THEIR PREPARATION AND USE VTVX HOLDINGS II LLC 2009-04-09 US disclosed
EP-1979311-A2 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS TRANSTECH PHARMA (US) 2008-10-15 EP disclosed
WO-2007071766-A2 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS TRANSTECH PHARMA (US) 2007-06-28 WO disclosed
EP-0842212-A4 IMIDE OLIGOMERS AND CO-OLIGOMERS CONTAINING PENDENT PHENYLETHYNYL GROUPS AND POLYMERS THEREFROM NASA (US) 1998-10-14 EP disclosed
EP-0842212-A1 IMIDE OLIGOMERS AND CO-OLIGOMERS CONTAINING PENDENT PHENYLETHYNYL GROUPS AND POLYMERS THEREFROM NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1998-05-20 EP disclosed
WO-1997006200-A1 IMIDE OLIGOMERS AND CO-OLIGOMERS CONTAINING PENDENT PHENYLETHYNYL GROUPS AND POLYMERS THEREFROM NATIONAL AERONAUTICS & SPACE ADMINISTRATION (US) 1997-02-20 WO disclosed
US-5446204-A Enhance density of thermosetting materials THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1995-08-29 US disclosed
US-5426234-A Compounds which are heat resistant at lower temperatures, but which polymerize at higher temperatures, also as reactive diluents or end groups for crosslinking THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1995-06-20 US disclosed
US-5312994-A Phenylethynyl endcapping reagents and reactive diluents THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1994-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10471066-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists PPARG, PPARA, PPARD ALDH1A1 487/4885SRD5A2 1293/4885APP 1696/4885
US-20090093484-A1 NOVEL COMPOUNDS, THEIR PREPARATION AND USE PPARG, PPARD, PPARA ALDH1A1 1084/4885SRD5A2 595/4885APP 3578/4885
US-11840607-B1 Cross-linkable thermoplastics, and processes of making and using same MTCL3, DUOX2, DUOX1 ALDH1A1 183/4885SRD5A2 2690/4885APP 1798/4885
US-10947180-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists PPARG, PPARA, PPARD ALDH1A1 487/4885SRD5A2 1293/4885APP 1696/4885
US-20180071304-A1 Phenoxy Acetic Acids and Phenyl Propionic Acids as PPAR Delta Agonists PPARG, PPARA, PPARD ALDH1A1 487/4885SRD5A2 1293/4885APP 1696/4885
US-20200215073-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS PPARG, PPARA, PPARD ALDH1A1 487/4885SRD5A2 1293/4885APP 1696/4885
US-20210188758-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS PPARG, PPARA, PPARD ALDH1A1 487/4885SRD5A2 1293/4885APP 1696/4885
US-12215195-B1 Cross-linkable thermoplastics, and processes of making and using same MTCL3, DUOX2, DUOX1 ALDH1A1 183/4885SRD5A2 2690/4885APP 1798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.