Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 17/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 17/20 | 0.46 |
| ▸ | GCK | P35557 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138682 | 0.85 | PTGS2 (0.36) | GCK | |
| SCHEMBL20138672 | 0.80 | PSEN1 (0.37) | GCK | |
| SCHEMBL28302622 | 0.72 | NR1H2 (0.47) | NR1H2NR1H3 | |
| SCHEMBL20138803 | 0.71 | SCN4A (0.38) | — | |
| SCHEMBL1889649 | 0.68 | PGR (0.48) | NR1H2NR1H3GCK | |
| SCHEMBL23492209 | 0.68 | PSEN1 (0.55) | NR1H2NR1H3GCK | |
| SCHEMBL20159274 | 0.68 | HTR2A (0.37) | — | |
| SCHEMBL20142944 | 0.68 | AR (0.33) | NR1H2NR1H3 | |
| SCHEMBL20159329 | 0.68 | PLA2G7 (0.40) | NR1H2NR1H3 | |
| SCHEMBL14018981 | 0.67 | NR1H2 (0.55) | NR1H2NR1H3GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790149-B | Phenoxytriazoles | 豪夫迈·罗氏有限公司 | 2022-05-17 | — | — | CN | disclosed |
| US-11319314-B2 | Phenoxytriazoles | HOFFMANN-LA ROCHE INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-11319314-B2 | Phenoxytriazoles | HOFFMANN-LA ROCHE INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-20210309653-A1 | PHENOXYTRIAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-20210309653-A1 | PHENOXYTRIAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3538516-B1 | PHENOXYTRIAZOLES | HOFFMANN LA ROCHE (CH) | 2021-06-16 | — | — | EP | disclosed |
| EP-3538516-A1 | PHENOXYTRIAZOLES | F. Hoffmann-La Roche AG (CH) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018087018-A1 | PHENOXYTRIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309653-A1 | PHENOXYTRIAZOLES | HTT, PSEN1, APP | NR1H2 666/4885NR1H3 1192/4885GCK 4468/4885 |
| US-11319314-B2 | Phenoxytriazoles | HTT, APP, PSEN1 | NR1H2 270/4885NR1H3 492/4885GCK 4404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.