Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HTR3A | P46098 | 1/20 | 0.63 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30343617 | 0.85 | TRIM24 (0.61) | ALDH1A1HTR3ATRIM24TRIM33APP | |
| SCHEMBL24989604 | 0.85 | TRIM24 (0.61) | ALDH1A1HTR3ATRIM24TRIM33APP | |
| SCHEMBL30343620 | 0.85 | TRIM24 (0.67) | ALDH1A1HTR3ATRIM24TRIM33APP | |
| SCHEMBL24988105 | 0.85 | TRIM24 (0.67) | ALDH1A1HTR3ATRIM24TRIM33APP | |
| SCHEMBL1688374 | 0.83 | ALDH1A1 (0.68) | ALDH1A1TRIM24TRIM33APPKDM4E | |
| SCHEMBL29663202 | 0.83 | ALDH1A1 (0.68) | ALDH1A1TRIM24TRIM33APPKDM4E | |
| SCHEMBL208547 | 0.83 | ALDH1A1 (1.00) | ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2 | |
| SCHEMBL1688379 | 0.81 | ALDH3A1 (0.56) | ALDH1A1TRIM24TRIM33APPKDM4E | |
| SCHEMBL31611878 | 0.81 | HTR3E (0.63) | ALDH1A1HTR3ATRIM24TRIM33KDM4E | |
| SCHEMBL1444185 | 0.80 | ALDH1A1 (0.64) | ALDH1A1HTR3AKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210138091-A1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2021-05-13 | — | — | US | disclosed |
| EP-3709022-A1 | USES OF LABELED HSP90 INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3208615-B1 | USES OF LABELED HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20170315137-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-02 | — | — | US | disclosed |
| EP-3208615-A2 | USES OF LABELED HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-2729806-B1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INST FOR CANCER RES (US) | 2017-02-22 | — | — | EP | disclosed |
| US-9555137-B2 | Uses of labeled HSP90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-01-31 | — | — | US | disclosed |
| US-9555137-B2 | Uses of labeled HSP90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-01-31 | — | — | US | disclosed |
| US-9551722-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150177262-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| EP-2509940-B1 | AMYLOID BINDING AGENTS | UNIV CALIFORNIA (US) | 2015-06-10 | — | — | EP | disclosed |
| US-8940918-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-27 | — | — | US | disclosed |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140242602-A1 | USES OF LABELED HSP90 INHIBITORS | CORNELL UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140242602-A1 | USES OF LABELED HSP90 INHIBITORS | CORNELL UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
| EP-2509940-A2 | AMYLOID BINDING AGENTS | The Regents of the University of California (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072257-A2 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170315137-A1 | AMYLOID BINDING AGENTS | APBA1, APP, PSEN1 | ALDH1A1 4267/4885HTR3A 2937/4885TRIM24 1982/4885 |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | HSP90AB1, HSP90B1, HSP90AA1 | ALDH1A1 2442/4885HTR3A 3983/4885TRIM24 2447/4885 |
| US-20210138091-A1 | USES OF LABELED HSP90 INHIBITORS | HSP90AB1, HSP90B1, HSP90AA1 | ALDH1A1 1352/4885HTR3A 4032/4885TRIM24 2124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.