Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.61 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A3 | P47895 | 5/20 | 0.49 |
| ▸ | TERT | O14746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30343617 | 1.00 | TRIM24 (0.61) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24988105 | 0.96 | TRIM24 (0.67) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL30343620 | 0.96 | TRIM24 (0.67) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1688374 | 0.95 | ALDH1A1 (0.68) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29663202 | 0.95 | ALDH1A1 (0.68) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL31611878 | 0.85 | HTR3E (0.63) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2013869 | 0.85 | ALDH1A1 (0.70) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1688379 | 0.85 | ALDH3A1 (0.56) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7180854 | 0.81 | TRIM24 (0.91) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL253732 | 0.77 | TRIM24 (1.00) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240325572-A1 | N-HETEROCYCLYL SUBSTITUTED 2-CYANO-3-(NAPHTHALEN-2-YL)ACRYLAMIDE DERIVATIVES AS FLUOROPHORS FOR DETECTION OF AMYLOID AND AMYLOID-LIKE PROTEINS FOR DIAGNOSIS OF NEURODEGENERATIVE DISORDERS | Amydis, Inc. | 2024-10-03 | — | — | US | disclosed |
| CN-117916225-A | N-heterocyclyl substituted 2-cyano-3- (naphthalen-2-yl) acrylamide derivatives as fluorophores for detection of amyloid and amyloid-like proteins for diagnosis of neurodegenerative disorders | 阿米达斯公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023288109-A1 | N-HETEROCYCLYL SUBSTITUTED 2-CYANO-3-(NAPHTHALEN-2-YL)ACRYLAMIDE DERIVATIVES AS FLUOROPHORS FOR DETECTION OF AMYLOID AND AMYLOID-LIKE PROTEINS FOR DIAGNOSIS OF NEURODEGENERATIVE DISORDERS | Amydis, Inc. (US) | 2023-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240325572-A1 | N-HETEROCYCLYL SUBSTITUTED 2-CYANO-3-(NAPHTHALEN-2-YL)ACRYLAMIDE DERIVATIVES AS FLUOROPHORS FOR DETECTION OF AMYLOID AND AMYLOID-LIKE PROTEINS FOR DIAGNOSIS OF NEURODEGENERATIVE DISORDERS | TARDBP, CDR2, NLN | TRIM24 3043/4885TRIM33 2836/4885ALDH1A1 2727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.