Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | APC | P25054 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CTSE | P14091 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138995 | 0.91 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL20142942 | 0.89 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL20159107 | 0.88 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL20142916 | 0.85 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL20142933 | 0.78 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL20159203 | 0.76 | PDE4D (0.44) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL20142960 | 0.74 | SMN1; SMN2 (0.41) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL20138970 | 0.73 | FPR1 (0.37) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL20159509 | 0.73 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL20142913 | 0.71 | SMN1; SMN2 (0.39) | PDE4BSMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |