Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140751 | 0.84 | MTOR (0.60) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20141516 | 0.83 | MTOR (0.46) | MTORRPTORMLST8ALDH1A1HSD17B10 | |
| SCHEMBL20140023 | 0.82 | MTOR (0.61) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20139966 | 0.82 | MTOR (0.61) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140531 | 0.81 | MTOR (0.49) | MTORRPTORMLST8ALDH1A1GAA | |
| SCHEMBL20156928 | 0.80 | MTOR (0.49) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140812 | 0.79 | ALDH1A1 (0.56) | ALDH1A1HSD17B10KDM4EHPGDGAA | |
| SCHEMBL20157035 | 0.78 | NPC1 (0.46) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140797 | 0.78 | KDM4E (0.58) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20141466 | 0.78 | MTOR (0.46) | MTORRPTORMLST8ALDH1A1SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |