Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MYC | P01106 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140725 | 0.89 | MTOR (0.47) | NAMPTMTORRPTORMLST8DRD2 | |
| SCHEMBL20139856 | 0.84 | NAMPT (0.52) | NAMPTMTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20141360 | 0.83 | NAMPT (0.51) | NAMPTMTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20140096 | 0.83 | PARP1 (0.45) | NAMPTMTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20140667 | 0.82 | TRPC5 (0.42) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20140604 | 0.81 | NAMPT (0.49) | NAMPTMTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20140103 | 0.80 | MTOR (0.46) | NAMPTMTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20140513 | 0.79 | DRD4 (0.41) | DRD2DRD4DRD3ALDH1A1TRPC5 | |
| SCHEMBL20140952 | 0.78 | NAMPT (0.54) | NAMPTMTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20156995 | 0.78 | TRPC5 (0.46) | MTORRPTORMLST8DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |