Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.43 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157255 | 0.90 | MTOR (0.40) | PARP1MTORRPTORMLST8CYP46A1 | |
| SCHEMBL20140648 | 0.89 | PRMT5 (0.42) | MTORRPTORMLST8CYP46A1PRMT5 | |
| SCHEMBL20140725 | 0.87 | MTOR (0.47) | PARP1MTORRPTORMLST8NAMPT | |
| SCHEMBL20140733 | 0.87 | KDM4E (0.48) | PRMT5WDR77DRD4KDM4EALDH1A1 | |
| SCHEMBL20140044 | 0.86 | MTOR (0.54) | PARP1MTORRPTORMLST8DRD4 | |
| SCHEMBL20139967 | 0.83 | NAMPT (0.48) | MTORRPTORMLST8NAMPTL3MBTL1 | |
| SCHEMBL20156931 | 0.82 | MTOR (0.51) | PARP1MTORRPTORMLST8L3MBTL1 | |
| SCHEMBL20140693 | 0.79 | HCRTR1 (0.49) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140587 | 0.79 | MTOR (0.54) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20139909 | 0.79 | LMNA (0.52) | PARP1MTORRPTORMLST8DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |